Infectious SARS-CoV-2 in Feces of Patient with Severe COVID-19

A number of research papers have now reported the detectable presence of SARS-CoV-2 RNA oligotides in the faeces of infected patients. Some of these have previously been summarised on this blog here. But the presence of RNA should not be misinterpreted to imply the presence of viable infectious virus particles (as has been pointed outContinue reading “Infectious SARS-CoV-2 in Feces of Patient with Severe COVID-19”

OPINION: Faecal shedding of SARS-CoV-2, a snapshot of current data and implications for the water industry

There has been quite some talk about SARS-CoV-2 shedding in faeces and what that might mean for the water industry.  As I see it, there are two aspects to this conversation: the first is a concern that sewage may contain infectious SARS-CoV-2 viruses; and the second relates to the more theoretical potential of using SARS-CoV-2Continue reading “OPINION: Faecal shedding of SARS-CoV-2, a snapshot of current data and implications for the water industry”

Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations

The WHO has recently released a scientific briefing on the modes of transmission of the COVID-19 virus, which can be accessed here. What does the briefing cover? The briefing defines the difference between droplets, which are larger than 5 microns and generated by coughing or sneezing, and droplet nuclei, which are less than 5 micronsContinue reading “Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations”

SARS-CoV-2–Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19

This study was reported as a letter to the scientific journal Annals of Internal Medicine on 30 March 2020. The authors report the outcomes of testing for SARS-CoV-2 RNA in sputum and faecal samples from COVID-19 patients after their apparent recovery, which was indicated by throat swabs no longer testing positive. The key finding wasContinue reading “SARS-CoV-2–Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19”

Survival of Severe Acute Respiratory Syndrome Coronavirus (2005)

This research paper was published in 2005 and relates to SARS-CoV (responsible for the 2002/03 SARS outbreak), not SARS-CoV-2 (responsible for COVID-19). However, since these two viruses are closely related, it is insightful to observe what is known about the former, in order to consider what may be possible (or even likely) for the latter.Continue reading “Survival of Severe Acute Respiratory Syndrome Coronavirus (2005)”

An Imperative Need for Research on the Role of Environmental Factors in Transmission of Novel Coronavirus (COVID-19)

On this blog, we have previously highlighted the recently produced open access Environmental Science and Technology ‘virtual issue’, collating numerous years of research on the fate and behaviour of enveloped viruses in the environment. This virtual issue includes a current “scientific opinion” (non-peer reviewed) piece by four researchers, Guangbo Qu (Chinese Academy of Sciences), XiangdongContinue reading “An Imperative Need for Research on the Role of Environmental Factors in Transmission of Novel Coronavirus (COVID-19)”

Viral Shedding and Antibody Response in 37 Patients with Middle East Respiratory Syndrome Coronavirus Infection

Middle East respiratory syndrome coronavirus (MERS-CoV) causes isolated cases and outbreaks of severe respiratory disease. This paper presents a study based on 37 adult patients infected with MERS-CoV. The aim was to assess the viral load (amount of virus) in the lower and upper respiratory tracts, blood, stool (faeces), and urine. A minority of faecesContinue reading “Viral Shedding and Antibody Response in 37 Patients with Middle East Respiratory Syndrome Coronavirus Infection”

Industrial experience and research into the causes of SARS virus transmission in a high-rise residential housing estate in Hong Kong

This report provides very practical insights as to how SARS-CoV is understood to have been transmitted among residents of a high-rise residential housing estate during the SARS outbreak in 2003. This transmission led to a localised outbreak (or ‘hotspot’) in the Amoy Gardens housing estate, in Hong Kong. It provides an important assessment of practicesContinue reading “Industrial experience and research into the causes of SARS virus transmission in a high-rise residential housing estate in Hong Kong”

The source and fate of pandemic viruses in the urban water cycle

This paper was produced by Dr Krista Rule Wigginton, Associate Professor in the Department of Civil and Environmental Engineering at the University of Michigan and two students under her supervision (Y. Ye and R.M. Ellenberg). It was commissioned by the Editors of the Royal Society of Chemistry journal “Environmental Science: Water Research & Technology” asContinue reading “The source and fate of pandemic viruses in the urban water cycle”

Excretion and detection of SARS coronavirus and its nucleic acid from digestive system (2005)

The aim of this study was to assess whether SARS coronavirus (SARS-CoV) could be excreted from the human digestive system. It was reported in the World Journal of Gastroenterology in 2005. Cell culture and semi-nested RT-PCR were used to detect SARS-CoV and its RNA from 21 stool and urine samples, and a kind of electropositiveContinue reading “Excretion and detection of SARS coronavirus and its nucleic acid from digestive system (2005)”